Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5657
Gene Symbol: PRTN3
PRTN3 		0.020 Biomarker disease BEFREE Myeloperoxidase ANCA is more common than proteinase-3 ANCA, and glomerulonephritis is the most common clinical presentation of ANCA-associated vasculitis in SSc. 31776158 2019
Entrez Id: 4353
Gene Symbol: MPO
MPO 		0.020 Biomarker disease BEFREE Myeloperoxidase ANCA is more common than proteinase-3 ANCA, and glomerulonephritis is the most common clinical presentation of ANCA-associated vasculitis in SSc. 31776158 2019
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.020 Biomarker disease BEFREE A brief recapitulation of the therapeutic potential of EZH2 targeting is provided.<b>Expert opinion</b>: There are questions marks and controversies surrounding the feasibility and safety of EZH2 targeting; it is recommended in RA and SLE, but queried in T1D, IBD, MS, and SSc. 31747802 2019
Entrez Id: 49
Gene Symbol: ACR
ACR 		0.100 Biomarker disease BEFREE The diagnosis of SSc was established in patients who met EULAR/ACR 2013 classification criteria. 31746507 2020
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.050 AlteredExpression disease BEFREE Previously, disturbances in plasma levels of angiotensin II (Ang II) and its antagonistic angiotensin-(1-7) (Ang-(1-7)) were found in patients with SSc. 31746507 2020
Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2 		0.010 Biomarker disease BEFREE SScAM occurred at a median [interquartile range (IQR)] time of 1 month [0-15] after SSc diagnosis. 31734403 2020
Entrez Id: 6370
Gene Symbol: CCL25
CCL25 		0.010 Biomarker disease BEFREE CCR9 + T helper (Th) cells can induce Sjögren-like symptoms in mice and both CCR9 + Th cells and their ligand CCL25 are increased in the salivary glands of primary Sjögren's syndrome (pSS) patients. 31733111 2020
Entrez Id: 2969
Gene Symbol: GTF2I
GTF2I 		0.020 GeneticVariation disease BEFREE Scleroderma Patient-centered Intervention Network-Scleroderma Support group Leader EDucation (SPIN-SSLED) program: non-randomised feasibility trial. 31719073 2019
Entrez Id: 10927
Gene Symbol: SPIN1
SPIN1 		0.010 GeneticVariation disease BEFREE Scleroderma Patient-centered Intervention Network-Scleroderma Support group Leader EDucation (SPIN-SSLED) program: non-randomised feasibility trial. 31719073 2019
Entrez Id: 84171
Gene Symbol: LOXL4
LOXL4 		0.010 Biomarker disease BEFREE The goal of this study was to use hSE and SAS to investigate cutaneous fibrosis and the role of LOXL4 in SSc pathogenesis. 31705627 2019
Entrez Id: 653361
Gene Symbol: NCF1
NCF1 		0.010 GeneticVariation disease BEFREE Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population. 31705128 2019
Entrez Id: 7421
Gene Symbol: VDR
VDR 		0.020 GeneticVariation disease BEFREE Associations of Vitamin D Receptor Single Nucleotide Polymorphisms with Susceptibility to Systemic Sclerosis. 31678895 2019
Entrez Id: 6775
Gene Symbol: STAT4
STAT4 		0.500 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 919
Gene Symbol: CD247
CD247 		0.460 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 10318
Gene Symbol: TNIP1
TNIP1 		0.440 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 54899
Gene Symbol: PXK
PXK 		0.120 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 4790
Gene Symbol: NFKB1
NFKB1 		0.110 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 3595
Gene Symbol: IL12RB2
IL12RB2 		0.110 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 23534
Gene Symbol: TNPO3
TNPO3 		0.110 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 9474
Gene Symbol: ATG5
ATG5 		0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 3594
Gene Symbol: IL12RB1
IL12RB1 		0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 57514
Gene Symbol: ARHGAP31
ARHGAP31 		0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 1609
Gene Symbol: DGKQ
DGKQ 		0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 1656
Gene Symbol: DDX6
DDX6 		0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 101928376
Gene Symbol: IL12A-AS1
IL12A-AS1 		0.100 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019